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David Miliband has announced he is to quit frontline politics after being pipped to Labour's leadership by his younger brother. The former foreign secretary has said he is not putting himself forward for a place in the shadow cabinet because it is the right decision for him, his family and for Labour.

Political Editor Michael Crick will asking what this means for Ed Miliband, and looking at David Miliband's life in politics. We'll have reaction to the news from a senior Labour politician.

Meanwhile, Jeremy has been speaking to Ed Miliband about who he is, and what he stands for. Does he believe in God for instance?

Plus we'll be asking our focus group of ex-Labour voters what they feel about having the younger Miliband at the party's helm.

Also in the programme, veteran US investigative journalist Bob Woodward - of Watergate fame - will be speaking exclusively to Gavin about the contents of his new book, Obama's Wars, which depicts a US administration deeply divided over strategy in Afghanistan.

We'll also have a report from Science Editor Susan Watts on Dr Robert Trossel, who has been struck off by the GMC following a Newsnight investigation into his controversial stem cell treatments.

Join Jeremy and Gavin at 10.30pm on BBC Two.

Ed Miliband delivered his maiden speech to the Labour party conference in Manchester earlier, telling delegates "I am ready to lead" and that a new generation was in charge of Labour with "different attitudes, different ideas, different ways of doing politics".

He concluded his speech saying: "We are the optimists and together we will change Britain."

Jeremy is in Manchester for us tonight with an audience of Labour members who'll give their views on the day's events.

David Grossman will give us his assessment of Ed's wide ranging speech - did he manage to reassure those who think the wrong brother won the leadership contest?

And our Political editor Michael Crick will give us his analysis of where the Labour Party is now, nearly five months on from its election defeat (and you can try your hand at Michael's latest conference season quiz - this week all about the Labour Party - by clicking here).

Then back in London Gavin will be speaking to the Archbishop of Canterbury, Dr Rowan Williams, about his new book - a collection of essays that looks at how we build a new social and economic model out of the ashes of the financial crisis.

All this and more at 10.30pm on BBC Two.

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